The hopes of NFL franchises â and their fanbases â often reside with their starting quarterbacks.
Let’s check out the odds for which signal-callers will start for six franchises, at DraftKings Sportsbook as of April 30.
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Cardinals Week 1 starting quarterback
Jacoby Brissett: -330 (bet $10 to win $13.03 total)
Gardner Minshew: +420 (bet $10 to win $52 total)
Carson Beck: +750 (bet $10 to win $85 total)
What to know: The Cardinals released seven-year starter Kyler Murray back in March, and he signed a one-year deal with the Vikings. With Murray battling injury much of last season, Brissett served as the Cardinals’ starter for 12 games, going 1-11 in those starts. Minshew will be on his fifth team in five years, and is 2-8 as a starter over the last two seasons. As for Beck, he was selected by Arizona in the third round of the 2026 NFL Draft.
Falcons Week 1 starting quarterback
Tua Tagovailoa: -125 (bet $10 to win $18 total)
Michael Penix Jr.: -102 (bet $10 to win $19.80 total)
What to know: This one is up in the air. Tagovailoa started 76 games over the past six seasons in Miami, going 44-32. In five of those years, the Dolphins had a winning record when Tagovailoa started, but Miami only made the playoffs once, losing in the wild-card round. He was released by Miami in March and signed a one-year deal with Atlanta. As for Penix, he’s started 12 games across two seasons with the Falcons, going 4-8, including 3-6 as the starter last season.
Browns Week 1 starting quarterback
Deshaun Watson: -135 (bet $10 to win $17.41 total)
Shedeur Sanders: +108 (bet $10 to win $20.80 total)
Dillon Gabriel: +5500 (bet $10 to win $560 total)
What to know: Watson enters his fifth season with the Browns, a tenure that has been marred by off-the-field issues and injuries, including a ruptured Achilles that caused him to miss the entire 2025-26 NFL season. In 19 starts for the Browns, Watson has gone 9-10, including 1-6 last season. Sanders, a rookie last season, went 3-4 in seven starts, while Gabriel â also a rookie â went 1-5 in six starts before Sanders took over.
Chiefs Week 1 starting quarterback
Patrick Mahomes: -720 (bet $10 to win $11.39 total)
Justin Fields: +500 (bet $10 to win $60 total)
Any other QB: +3500 (bet $10 to win $360 total)
What to know: This one is all about health. Mahomes tore his ACL in Week 15 of last season (Dec. 14, 2025), but the odds suggest that he will be ready for Week 1. If, for some reason, he is not ready to play, Kansas City traded for Fields in March. Fields started nine games for the Jets last season, going 2-7.
Raiders Week 1 starting quarterback
Kirk Cousins: -200 (bet $10 to win $15 total)
Fernando Mendoza: +168 (bet $10 to win $26.80 total)
Any other QB: +2000 (bet $10 to win $210 total)
